Misc. Stock Option Grant Programs

AMENDED AND RESTATED STOCK OPTION GRANT

PROGRAM FOR NONEMPLOYEE DIRECTORS UNDER THE

ICOS CORPORATION 1999 STOCK OPTION PLAN

The following provisions set forth the terms of the stock option grant program for nonemployee directors of ICOS Corporation (the �Company�) under the ICOS Corporation 1999 Stock Option Plan (the �Plan�). The following terms are intended to supplement, not alter or change, the provisions of the Plan, and in the event of any inconsistency between the terms contained herein and in the Plan, the Plan shall govern. All capitalized terms that are not  . . .